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Apoptosis Activator 2

Apoptosis Activator 2

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Product Code: 3033
Availability: In Stock
$180.00
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Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.

Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione

Inhibitors Proteases Caspase Apoptosis Activator 2 79183-19-0
Biological Activity:
Biological Activity Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.
Technical Data:
M.W. 306.14
Formula: C<sub>15</sub>H<sub>9</sub>Cl<sub>2</sub>NO<sub>2</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 79183-19-0
References:
References Nguyen JT, et al. Proc Natl Acad Sci U S A, 2003, 100(13), 7533-7538. lavian KN, et al. Neural Dev, 2009, 16(4), 11. Farivar TN, et al. N Am J Med Sci, 2012, 4(11), 582-585. Nguyen TV, et al. J Neuroendocrinol, 2010, 22(9), 1013-1022.

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