Wishlist (0)
Welcome visitor Login or Register.
My Cart    0 $0.00
Your shopping cart is empty!
Dorzolamide HCl

Dorzolamide HCl

0 reviews Write a review
Product Code: 3121
Availability: In Stock
$133.00
-+

Dorzolamide HCl is a carbonic anhydrase inhibitor.

Chemical Name:

4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride

Inhibitors Metabolism Carbonic Anhydrase Dorzolamide HCl 130693-82-2
Biological Activity:
Biological Activity Dorzolamide HCL is a hydrochloride salt of dorzolamide. Dorzolamide is a potent inhibitor of human carbonic anhydrase isoenzyme II. The IC50 of dorzolamide is 0.18 nM in vitro. For a comparison, the inhibitory activity of dorzolamide against human carbonic anhydrase isozyme I is much weaker with an IC50 of 600 nM.[1] When 20 or 200 µM dorzolamide is incubated with human erythrocytes, 98% or 71% of dorzolamide is taken up by the erythrocytes, respectively. Dorzolamide has a high affinity for human carbonic anhydrase isoenzyme II with a Kd of 1.1 nM. [2] Dorzolamide decreases intraocular pressure via reducing aqueous humor production
Technical Data:
M.W. 360.9
Formula: C<sub>10</sub>H<sub>16</sub>N<sub>2</sub>O<sub>4</sub>S<sub>3</sub>.HCl
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 130693-82-2
References:
References Plummer CE, MacKay EO, Gelatt KN: Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs. Vet Ophthalmol. 2006 Jul-Aug;9(4):245-9. Grover S, Apushkin MA, Fishman GA: Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa. Am J Ophthalmol. 2006 May;141(5):850-8. Epub 2006 Mar 20. Almeida GC Jr, Faria e Souza SJ: Effect of topical dorzolamide on rabbit central corneal thickness. Braz J Med Biol Res. 2006 Feb;39(2):277-81. Epub 2006 Feb 2. Martens-Lobenhoffer J, Banditt P: Clinical pharmacokinetics of dorzolamide. Clin Pharmacokinet. 2002;41(3):197-205 Balfour JA, Wilde MI: Dorzolamide. A review of its pharmacology and therapeutic potential in the management of glaucoma and ocular hypertension. Drugs Aging. 1997 May;10(5):384-403. Ponticello GS, Sugrue MF, Plazonnet B, Durand-Cavagna G: Dorzolamide, a 40-year wait. From an oral to a topical carbonic anhydrase inhibitor for the treatment of glaucoma. Pharm Biotechnol. 1998;11:555-74.

Write a review

Note: HTML is not translated!
    Bad           Good
Continue

About HDH PHARMA

At HDH Pharma, we are committed to offering our clients the highest quality research services with the most convenient and effective communications from both US and Indian operations. Clients in the Americas and Europe can pick up the phone and speak directly with our scientists in the US. Clients in Asia can receive the same rapid response from our scientists in India. HDH’s hybrid operation is designed with our client’s operational needs in mind.


Information

Extras

My Account

Powered By Nsoft Solutions
HDH PHARMA © 2024