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Gimeracil

Gimeracil

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Product Code: 3156
Availability: In Stock
$146.00
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A potent inhibitor of dihydropyrimidine dehydrogenase (DPD)

Chemical name :

 5-Chloro-4-hydroxy-2(1H)-pyridinone

Inhibitors Metabolism Dehydrogenase Gimeracil 103766-25-2 5-Chloro-4-hydroxy-2(1H)-pyridinone; 5-Chloro-2 4-dihydroxypyridine; 5-Chloro-4-hydroxy-2-pyridone; Gimestat; CDHP
Biological Activity:
Biological Activity Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase (DPYD), which degrades pyrimidine including 5-fluorouracil in the blood. Gimeracil inhibits homologous recombination.
Technical Data:
M.W. 145.54
Formula: C<sub>5</sub>H<sub>4</sub>ClNO<sub>2</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 103766-25-2
References:
References Sakata K, et al. Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. Cancer Sci. 2011 Sep;102(9):1712-6. Takagi M, et al. Gimeracil sensitizes cells to radiation via inhibition of homologous recombination. Radiother Oncol. 2010 Aug;96(2):259-66.

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