GW501516

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Product Code: 3169
Availability: In Stock

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GW501516 is a potent and highly selective PPARβ/δ agonist, with EC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. Phase 4.

Chemical Name : 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid

Biological Activity:
Biological Activity	GW501516 is a potent and highly selective PPARβ/δ agonist, with EC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. Phase 4
Technical Data:
M.W.	453.50
Formula:	C<sub>21</sub>H<sub>18</sub>F<sub>3</sub>NO<sub>3</sub>S<sub>2</sub>
Solubility:
Purity:
Storage:	6 months-80℃in DMSO
CAS No:	317318-70-0
References:
References	Sznaidman ML, et al. Bioorg Med Chem Lett, 2003, 13(9), 1517-1521. Oliver WR Jr, et al. Proc Natl Acad Sci U S A, 2001, 98(9), 5306-5311. Xu HE, et al. Mol Cell, 1999, 3(3), 397-403. Dressel U, et al. Mol Endocrinol, 2003, 17(12), 2477-2493. Coll T, et al. Endocrinology, 2010, 151(4), 1560-1569. Antoinette Defaux, et al. J Neuroinflammation, 2009, 6, 15. Tanaka T, et al. Proc Natl Acad Sci U S A, 2003, 100(26), 15924-15929.

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