BADGE

0 reviews Write a review

Product Code: 6822
Availability: In Stock

$0.00

MG Options

Qty

Alternative Name: Bisphenol A diglycidyl ether

Chemical Name: 2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane

Biological Activity:
Biological Activity	PPARγ pure antagonist with micromolar affinity in 3T3-L1 and 3T3-F442A preadipocyte cells; selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ. Acts as a PPARγ agonist in an ECV304 cell line. Also produces PPARγ-independent apoptosis of tumor cells via several mechanisms. Active in vivo.
Technical Data:
M.W.	340.42
Formula:	C<sub>21</sub>H<sub>24</sub>O<sub>4</sub>
Solubility:	Soluble to 50 mM in ethanol and to 100 mM in DMSO
CAS No:	1675-54-3
References:
References	Bishop-Bailey et al (2000) Bisphenol A diglycidyl ether (BADGE) is a PPARγ agonist in an ECV304 cell line. Br.J.Pharmacol. 131 651. PMID: 11030710. Wright et al (2000) A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation. J.Biol.Chem. 275 1873. PMID: 10636887. Fehlberg et al (2003) Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO. Br.J.Pharmacol. 139 495. PMID: 12788809. Cuzzocrea et al (2004) Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation. Eur.J.Pharmacol. 483 79. PMID: 14709329.

Write a review

Your Name

Your Review Note: HTML is not translated!

Rating Bad Good