Bupivacaine HCl

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Product Code: 3079
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Bupivacaine HCl is a more potent cAMP production inhibitor with an IC50 of 2.3 μM

Chemcial name 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

Biological Activity:
Biological Activity	Bupivacaine hydrochloride(Marcain) is a more potent cAMP production inhibitor with an IC50 of 2.3 µM. It more potently inhibited basal cAMP production than either ropivacaine (IC50 = 4 µM) or mepivacaine (IC50 = 32 µM). Similarly, it was as potent as ropivacaine (IC50 = 1.7 µM) and more potent than mepivacaine (IC50 = 8.9 µM) at inhibiting epinephrine-stimulated cAMP production. Bupivacaine (IC50 = 5.3 µM) was only marginally more potent than ropivacaine (IC50 = 9.7 µM) or mepivacaine (IC50 = 6.8 µM) at inhibition of forskolin-stimulated cAMP production. Comparison of epinephrine concentration-response curves in the presence and absence of bupivacaine (0.35, 3.5, and 35 µM ) demonstrated noncompetitive inhibition of cAMP production by the local anesthetic.
Technical Data:
M.W.	324.89
Formula:	<p>C<sub>18</sub>H<sub>28</sub>N<sub>2</sub>O.HCl</p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	18010-40-7

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