Thalidomide

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Product Code: 3220
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Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex.Phase 3.

Chemical Name:
(RS)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione

Biological Activity:
Biological Activity	Thalidomide was introduced as a sedative drug in the late 1950s. However, it was withdrawn due to a teratogenic effect on fetal development. Thalidomide binds to inactivate the protein cereblon, which is important to limb formation. [1] There is now a growing clinical interest in thalidomide since it is introduced as an immunomodulatory agent used primarily, combined with dexamethasone, to treat multiple myeloma. The combination of thalidomide and dexamethasone, often in combination with melphalan, is now one of the most common regimens for patients with newly diagnosed multiple myeloma, with an improved response rate of up to 60-70%.
Technical Data:
M.W.	258.23
Formula:	C<sub>13</sub>H<sub>10</sub>N<sub>2</sub>O<sub>4</sub>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	50-35-1
References:
References	Strömland K, Miller MT. Thalidomide embryopathy: revisited 27 years later. Acta Ophthalmol (Copenh). 1993;71 (2): 238-45. Gupta RC. Reproductive and Developmental Toxicology. Academic Press. (2011) ISBN:0123820332.

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Thalidomide

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