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VX-680

VX-680

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Product Code: 3185
Availability: In Stock
$180.00
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VX-680 (Tozasertib, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. Phase 2.

Chemical Name:
N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide

Inhibitors Cell Cycle Aurora Kinase VX-680 639089-54-6
Biological Activity:
Biological Activity VX-680 (Tozasertib, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. Phase 2.
Technical Data:
M.W. 464.59
Formula: C<sub>23</sub>H<sub>28</sub>N<sub>8</sub>OS
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 639089-54-6
References:
References Harrington EA, et al. Nat Med. 2004, 10(3), 262-267. Arlot-Bonnemains Y, et al. Endocr Relat Cancer. 2008, 15(2), 559-568. Young MA, et al. Cancer Res. 2006, 66(2), 1007-1014.

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