Ivacaftor (VX-770)

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Product Code: 3417
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Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.

Chemical Name N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Biological Activity:
Biological Activity	Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
Technical Data:
M.W.	392.49
Formula:	<p>C<sub>24</sub>H<sub>28</sub>N<sub>2</sub>O<sub>3</sub></p>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	873054-44-5
References:
References	Van Goor F, et al. Proc Natl Acad Sci U S A, 2009, 106(44), 18825-18830.

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