Anacetrapib (MK-0859)

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Product Code: 3029
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Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.

Chemical Name: 2-Oxazolidinone, 5-[3,5-bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-2'-methoxy-5'-(1-methylethyl)-4-(trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl]-4-methyl-, (4S,5R)-

Biological Activity:
Biological Activity	Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. Phase 3.
Technical Data:
M.W.	637.51
Formula:	C<sub>30</sub>H<sub>25</sub>F<sub>10</sub>NO<sub>3</sub>
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	875446-37-0
References:
References	Niesor EJ, et al. J Lipid Res. 2010, 51(12), 3443-3454. Ranalletta M, et al. J Lipid Res. 2010, 51(9), 2739-2752. Tan EY, et al. Drug Metab Dispos. 2010, 38(3), 459-473.

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Anacetrapib (MK-0859)

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