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Cyclopamine

Cyclopamine

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Product Code: 3103
Availability: In Stock
$335.00
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Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.

Chemical Name

Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol, 1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-, (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-

Inhibitors Stem Cells & Wnt Hedgehog/Smoothened Cyclopamine 4449-51-8
Biological Activity:
Biological Activity Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.
Technical Data:
M.W. 411.62
Formula: C<sub>27</sub>H<sub>41</sub>NO<sub>2</sub>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 4449-51-8
References:
References Peukert S, et al. Bioorg Med Chem Lett, 2009, 19(2), 328-331. Berman DM, et al. Nature, 2003, 425(6960), 846-851. Thayer SP, et al. Nature, 2003, 425(6960), 851-856. Feldmann G, et al. Cancer Res, 2007, 67(5), 2187-2196.

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