RO4929097

RO4929097

Product Code: 3278
Availability: In Stock
$398.00
-+

RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.

Chemical Name: Propanediamide, N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-

Biological Activity:
Biological Activity RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.
Technical Data:
M.W. 469.4
Formula: <p>C<sub>22</sub>H<sub>20</sub>F<sub>5</sub>N<sub>3</sub>O<sub>3</sub></p>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 847925-91-1
References:
References Luistro L, et al. Cancer Res. 2009, 69(19), 7672-7680. Debeb BG, et al. Breast Cancer Res Treat. 2012. Huynh C, et al. PLoS One. 2011, 6(9), e25264. He W, et al. Mol Oncol. 2011, 5(3), 292-301. Li YM, et al. Proc Natl Acad Sci U S A. 2000, 97(11), 6138-6143.

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