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ABT-737

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Product Code: 3004
Availability: In Stock
$247.00
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ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2.

Chemical Name Benzamide, 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-

Inhibitors Apoptosis Bcl-2 ABT-737 852808-04-9
Biological Activity:
Biological Activity ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2.
Technical Data:
M.W. 813.43
Formula: <h1>&nbsp;&nbsp;C<sub>42</sub>H<sub>45</sub>ClN<sub>6</sub>O<sub>5</sub>S<sub>2</sub></h1>
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 852808-04-9
References:
References Konopleva M, et al. Cancer Cell, 2006, 10(5), 375-388. van Delft MF,et al. Cancer Cell, 2006, 10(5), 389-399. Del Gaizo Moore V, et al. J Clin Invest, 2007, 117(1), 112-121. Tahir SK, et al. Cancer Res, 2007, 67(3), 1176-1183. Ishitsuka K, et al. Cancer Lett, 2012, 317(2), 218-225. Konopleva M, et al. Cancer Res, 2008, 68(9), 3413-3420. Wade M, et al. Cell Cycle, 2008, 7(13), 1973-1982. Paoluzzi L, et al. Blood, 2008, 112(7), 2906-2916. Li R, et al. Mol Pharmacol, 2009, 75(5), 1231-1239.

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