10074-G5

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Product Code: 9715
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An inhibitor of c-Myc-Max interaction

Chemical Name
7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine, Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-ylamine

Biological Activity:
Biological Activity	A c-Myc Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4, specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM) most likely due to the fact that 10074-G5 binds to a different region of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.
Technical Data:
M.W.	332.31
Formula:	C<sub>18</sub>H<sub>12</sub>N<sub>4</sub>O<sub>3</sub>
Solubility:	Soluble in DMSO and DMF
CAS No:	413611-93-5
References:
References	Follis, A.V., et al., Structural rationale for the coupled binding and unfolding of the c-Myc oncoprotein by small molecules. Chem. Biol. 15, 1149-1155, (2008); Yin, X., et al., Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22, 6151-6159, (2003)

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