JIB 04

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Product Code: 6887
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Pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.

Chemical Name: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine

Technical Data:
M.W.	308.76
Formula:	C17H13ClN4
Solubility:	Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:	>99 %
Storage:	Store at +4°C
CAS No:	199596-05-9

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At HDH Pharma, we are committed to offering our clients the highest quality research services with the most convenient and effective communications from both US and Indian operations. Clients in the Americas and Europe can pick up the phone and speak directly with our scientists in the US. Clients in Asia can receive the same rapid response from our scientists in India. HDH’s hybrid operation is designed with our client’s operational needs in mind.

JIB 04

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