Zibotentan

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Product Code: 3176
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Zibotentan (ZD4054) is a specific Endothelin (ET)Aantagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.

Chemical Name:
2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid

Biological Activity:
Biological Activity	Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
Technical Data:
M.W.	424.43
Formula:	C<sub>19</sub>H<sub>16</sub>N<sub>6</sub>O<sub>4</sub>S
Solubility:	DMSO
Purity:	98%
Storage:	-20℃
CAS No:	186497-07-4
References:
References	Morris CD, et al. Br J Cancer, 2005, 92(12), 2148-2152. Rosanò L, et al. Exp Biol Med (Maywood), 2006, 231(6), 1132-113 Rosanò L, et al. Cancer Res, 2007, 67(13), 6351-635 Rosanò L, et al. Mol Cancer Ther, 2007, 6(7), 2003-201

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