IKK Inhibitor IV

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Product Code: 9783
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A potent inhibitor of IKK beta (IKK-2).

Chemical Name: 2-(Carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide

Biological Activity:
Biological Activity	IKK-2 inhibitor IV is a potent inhibitor of IKKβ (IKK-2) which interferes with NF-κB DNA binding and therefore expression of many inflammatory genes. Inhibits lipopolysaccharide-induced human monocyte production of TNF-α and decreases the severity of murine collagen-induced arthritis. Shown to reduce Endothelin-1 stimulated Monocyte Chemotactic Protein-1 production in human airway smooth muscle cells. Also inhibits up-regulation of bradykinin B1 and B2 receptor-mediated contractions. IKK-2 Inhibitor IV is an inhibitor of IKKα.
Technical Data:
M.W.	279.3
Formula:	C<sub>12</sub>H<sub>10</sub>FN<sub>3</sub>O<sub>2</sub>S
Solubility:	Soluble in DMSO (56 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Storage:	Store at 4° C
CAS No:	507475-17-4
References:
References	1. Birrell, M.A., et al. 2005. Am. J. Respir. Crit. Care Med. 172: 962-971. PMID: 16002568 2. Podolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312: 373-381. PMID: 15316093 3. Birrell, M.A., et al. 2006. Mol. Pharmacol. 69: 1791-1800. PMID: 16517756 4. Kondo, Y., et al. 2008. Invest. Ophthalmol. Vis. Sci. 49: 4850-4857. PMID: 18676628 5. Sutcliffe, A.M., et al. 2009. Br. J. Pharmacol. 157: 436-450. PMID: 19371341 6. Lei, Y., et al. 2010. Eur. J. Pharmacol. 634: 149-161. PMID: 20184874

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