OU749

0 reviews Write a review

Product Code: 9795
Availability: In Stock

$0.00

MG Options

Qty

A non-glutamine uncompetitive GGT inhibitor.

Chemical Name: N-[5-(4-methoxybenzyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide

Biological Activity:
Biological Activity	Gamma-glutamyl transpeptidase (GGT; aka gamma-glutamyl transferase) cleaves the gamma-glutamyl bond of glutathione, making extracellular glutathione available for intracellular use. Elevated intracellular glutathione contributes to resistance of tumors to chemotherapy and radiation. GGT is a therapeutic target for treatment-resistance cancers, as treatment with GGT inhibitors prior to chemotherapy or radiation could sensitize GGT-positive tumors to treatment by decreasing glutathione levels. Previously, all GGT inhibitors have been glutamine analogues, which are competitive for the gamma-glutamyl site. Due to high toxicity, these compounds cannot be used in the clinic. OU749 is the first non-glutamine GGT inhibitor. It is also non-competitive for the gamma-glutamyl site. OU749 inhibits human GGT in an enzyme assay and is much less toxic than other GGT inhibitors, including azaserine (glutamine analogue, Sigma catalog).
Technical Data:
M.W.	361.44
Formula:	C<sub>16</sub>H<sub>15</sub>N<sub>3</sub>O<sub>3</sub>S<sub>2</sub>
Solubility:	Soluble in DMSO: >20 mg/mL
Storage:	Store at 4° C
CAS No:	519170-13-9

Write a review

Your Name

Your Review Note: HTML is not translated!

Rating Bad Good